ELC8 - ELC8 – Puberty: HPG Axis Maturation

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Covers the hormonal control of puberty including GnRH, LH/FSH, sex steroids, kisspeptin, and maturation of the HPG axis from childhood to adult function.

Créé par

Millicent C

Australia

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ELC8 - ELC8 – Puberty: HPG Axis Maturation


ELC8 - ELC8 – Puberty: HPG Axis MaturationVersion en ligne Covers the hormonal control of puberty including GnRH, LH/FSH, sex steroids, kisspeptin, and maturation of the HPG axis from childhood to adult function. par Millicent C 1 Early life HPG axis activity From mini-puberty after birth to childhood suppression. Brief activation of HPG axis after birth “mini-puberty” Temporary rise in LH, FSH, and sex steroids Low-amplitude circadian GnRH pulses secretion persists Postnatal decline of GnRH, LH, and FSH secretion HPG axis enters suppressed state Strong negative feedback maintains low sex steroid levels 2 Pre-pubertal to early pubertal transition From pre-pubertal state to early pubertal activation. Increased GnRH pulse frequency and small amplitude peaks in early hours of morning during sleep (diurnal pattern) Similar sex-hormone binding globulin levels exist in people with ovaries and testes, binding most circulating sex steroids pre-puberty Gonadotropins become less sensitive to negative feedback; HPG axis begins switching on. Kisspeptin neurons activate GnRH neurons, positive feedback overcomes HPG axis suppression 3 Early puberty to maturation shift From early puberty to adult pulsatility pattern. LH and FSH pulses occur primarily during sleep Gonadal sex steroid production increases and secondary sexual characteristics begin to appear LH and FSH pulses become more frequent during the day Loss of diurnal rhythm in GnRH/LH/FSH secretion begins 4 HPG axis signalling Hormone signalling from pituitary to gonads. Spermatogenesis and ovarian cycle Kisspeptin stimulates GnRH neurons in hypothalamus GnRH stimulates anterior pituitary gonadotrophs LH stimulates Leydig/theca cells and FSH stimulates Sertoli/granulosa cells LH and FSH are released into circulation Testosterone, oestradiol, and progesterone production increases 5 Adult reproductive function From late puberty to full maturity. Continuous pulsatile GnRH release across the day Stable pulsatile GnRH/LH/FSH signalling Testosterone decreases sex hormone binding globulin; oestrogen increases SHBG. Mature gonadal steroid production maintained Established loss of diurnal rhythm in GnRH secretion Full fertility and adult reproductive function achieved.

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ELC8 - ELC8 – Puberty: HPG Axis Maturation

Rangées

À propos de cette activité

Créé par

Téléchargez la version pour jouer sur papier

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ELC8 - ELC8 – Puberty: HPG Axis MaturationVersion en ligne

par Millicent C

Early life HPG axis activity From mini-puberty after birth to childhood suppression.

Pre-pubertal to early pubertal transition From pre-pubertal state to early pubertal activation.

Early puberty to maturation shift From early puberty to adult pulsatility pattern.

HPG axis signalling Hormone signalling from pituitary to gonads.

Adult reproductive function From late puberty to full maturity.