Preguntas para la parte de inmuno
1
Which papillomavirus proteins are responsible for cell immortalization?
2
Which is the only animal virus that has ribozyme activity?
3
Viruses that require yearly vaccination due to their high variability, which type of polymerase do they have?
4
Which of the following statements about type I interferons is incorrect?
5
What is the main difference between IFN-inducing PRRs and CLRs?
6
Which of the following statements about hepatitis delta virus (HDV) is incorrect?
7
Influenza virus binds sialic acid, which is present in many human cells. Therefore:
8
Which statement about rotavirus host susceptibility is correct?
9
Which of the following mechanisms is NOT a known viral strategy to evade NK cell-mediated immunity?
10
What is cross-presentation in dendritic cells?
11
Which of the following is NOT a cytosolic PRR involved in viral detection?
12
Which of the following statements about immunity is correct?
13
Which of the following is NOT a general type of viral transmission?
14
Which of the following virus families is enveloped?
15
Which statement about MHC-I vs MHC-II is correct?
16
Which is NOT a function of adaptive antiviral immunity?
17
Which thymic selection process eliminates autoreactive T cells?
18
What is the main goal antiviral drugs?
19
Why is selective toxicity difficult to achieve with antiviral drugs?
20
Viral quasispecies refers to:
21
Why do viruses develop resistance to antiviral drugs so easily?
22
What does ADMET stand for
23
Which of the following is a strategy used for antiviral drug discovery?
24
The Selectivity Index (SI) of an antiviral drug is defined as:
25
Which principle best describes how antiviral drugs work?
26
Which of the following ia NOT a target of direct-acting antivirals (DAA) against hepatitis C virus?
27
Which of the following statements about RNA viruses and antiviral resistance is FALSE?
28
Both HIV and HCV are treated with combination antiviral therapy. What is the main difference?
Feedback
RNA-dependent RNA polymerase
They are exclusively produced by B lymphocytes (by all nucleated cells)
IFN-inducing PRRs detect viral nucleic acids, whereas CLRs recognize carbohydrates present in pathogen glycoproteins
Infection only occurs during simultaneous coinfection with hepatitis B virus (it can happen after)
Only some cells with sialic acid are permissive
P[8] infects mainly secretor individuals, whereas P[6] infects more frequently Lewis-negative individuals
Viral secretion of granzymes to kill NK cells (NK cells secrete granzymes to kill infected cells)
Presentation of exogenous antigens on MHC-I (MHC-I usually present endogenous antigens, and they are on all nucleated cells)
TLR3 (Toll-like receptor)
Adaptive immunity is characteristic of vertebrates
Vectorial intracellular
MHC-I is on all nucleated cells, MHC-II on APCs
PAMP recognition (innate immunity)
Inhibit viral replication
Viruses depend on host cell processes
A mixture of related viral mutants
Absortion, Disruption, Metabolism, Excretion and Toxicity
The ratio between CC50 and IC50, indicating the balance between toxicity and antiviral activity
They inhibit viral replication and rely on the host immune system to clear the infection
Their RNA genome is unstable, making resistance less likely
HIV requires lifelong combination therapy, while HCV can often be cured with DAA treatment
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