Relier Pairs Compounding weeks 1-13Version en ligne GANG U NEED TO DO GOOD IN THEORY OR ELSE YOU WILL FAIL par Audree Dulnuan 1 HPR 2 Extreme danger 3 WHMIS 4 What are key elements of WHMIS 5 Upside down triangle border 6 Danger 7 What is HPA regulates? 8 Caution 9 GHS (WHMIS 2015) 10 CPR 11 Octagon border 12 When did WHMIS came into effect 13 HPA 14 What does GHS (WHMIS 2015) do? Hazardous products regulations Hazardous Products Act Globally harmonized system Workplace Hazardous Materials Information System Hazard classification, cautionary labelling of containers, provision of MSDSs, worker education programs Means that the contents of the container are dangerous Means exposure w even small amounts of the product may cause temporary or permanent injury or death. Defines & classifies the hazards through labels & safety data sheets. Set labelling & MSDS requirements for suppliers. Means the injury will most likely be temporary, but death may occur w extreme exposure Means the products may cause temporary or permanent injury or death. Means that the container itself is dangerous Controlled product regulations October 31, 1988 (The first whmis) 1 2 3 4 5 6 7 8 9 10 Hazards to the environment Biohazardous infectious materials Skull & crossbones (acute toxicity) Exploding bomb (explosive) Gas cylinder (gass under pressure) Health hazard Flame (flammable) Corrosion Flame over circle (oxidizing) Exclamation mark (health hazards) 1 Hariy areas 2 Wet/oozy skin conditions 3 Dry, scaly skin conditions 4 Humectant 5 Cream 6 Emollient 7 Occlusive 8 Oleaginous 9 Skin folds 10 Inflamed skin 11 Cracks & sores 12 Palms & soles 13 Stratum corneum 14 Mucosal surfaces 15 Lotion 16 Gel 17 Ointment Non-irritating formulations to avoid irritating eroded surfaces Usually considered thicker than a solution & more likely to contain oil as well as water or alcohol Use a cream or a lotion Ointment or cream may be preffered Semi-solid, water-free (80% oil), 6 months exp. Thicker than a lotion 70% water & 30% grease, a 50/50 emulsion of oil & water (30 days exp.) Substance that promotes retention of water in the skin by forming a barrier that prevents moisture in the skin ointments & oils are appropriate rich in, covered w, producing oil, oily/greasy Substance that causes water retention Agent which softens the skin or soothes irritation on skin Bland preparations; avoid alcohol & acidic preparations. Wet compresses & soaks followed by creams/ointments Bricks & mortar allow substances to pass Aqueous or alcoholic monophasic semisolid emulsion Lotion, solution, gel or foam creams, lotions, & drying pastes 1 What levigating agent is used for ointment? 2 What levigating agent is used for cream? 3 Pharmacy manager/pharmacy department head 4 What does centennial college use as an alternative w MFR/CR 5 Non-regulated personnel 6 Compounding Record-CR 7 MFR-Master Formulation Records 8 Regulated Pharmacy personel 9 Non-sterile compounding supervisor Mineral oil Can only perform assigned compounding tasks under supervision after proper training Recipe, list of instructions, ingredient list/preparation instructions Oversees the entire pharmacy Specifically manages & supervises compounding activities Responsible & accountable for compounding & patient care Patient-specific preparation, lot, exp, weights, names, quality control Glycerin MFS-Master formula sheet 1 Moderate 2 Group 3 3 Risk assessment 4 Simple 5 Methylparaben & propylparaben 6 Level C 7 Level A 8 Group 2 9 Level B 10 Group 1 11 NIOSH 12 Tween 20 & Tween 80 13 Complex National Institute for Occupational Safety & Health Non-antineoplastic drugs, pose reproductive risk Requires special training, environment, facilities, equipment. Emulsifying agents Preparing using USP monograph-specified ingredients, procedures, equipment, stability/BUD and following manufacturer directions Requires special calculations/procedures separate space when compounding simple & complex. Must be reviewed every 12 months. Antineoplastic drugs (cytotoxic drugs) Dedicated room, complex preparations, or small quantities need more training w no interruptions. Dedicated room & negative pressure, C-PEC anti-fungal preservative Non-antineoplastic drugs, meets one or more NIOSH hazardous drugs 1 Menthol, crystals 2 Elixirs 3 Density 4 Specific gravity 5 Solutions 6 Mixing liquids techniques 7 Menthol & camphor 8 Syrups 9 Relative density less than 1 10 Aromatic waters 11 Compounding Techniques for Oral Elixirs 12 Eutectic Mixture 13 Urea 14 Density formula 15 Relative density is exactly 1 16 Suspension 17 Relative density greater than 1 18 Specific gravity formula Needs to be dissolved in alcohol, anti-pruritic Substance would float Liquids that contain ingredients, both active & inert, not soluble in the vehicle Density of substance/density of water Ratio of a substance's weight to the weight of same volume of water Solutions that are sweetened & alcohol-based (5%-40%) Dissolved in boiling water, emollient agent g/ml mass/volume The substance would sink Clear liquid preparations Clear saturated aqueous solutions of volitile oils or aromatic substances A mixture of 2 or more components that do not mix together forms into a liquid. Quantity of mass & volume, absolute term, P Use to improve the taste some foul or bitter tasting active ingredients The density is the same as water Anti-pruritic, eutectic mixture Higher density liquid should be added to lower density liquids while constantly stirring. Water component is added to the alcohol component 1 Why is 70% most effective? 2 Methylcellulose 3 99% Alcohol 4 Alcohol in 12yrs & up 5 Sodium benzoate 6 Sucrose 7 Chlorhexidine 8 Lower concentration of alcohol 9 OTC prodcuts that contains alcohol 10 Alcohol in 6yrs-12yrs old 10 % max alcohol Antiseptic, effective against gram-negative/positive bacteria, yeast, fungi 50% of alcohol and lower may be less effective & requires more time Max alcohol 5% Antiseptic, vehicle, diluent Less than 6yrs old should be alcohol-free. 60%-90% alcohol is effective anti-fungal, added to oral liquids to prevent fungal growth Suspending agent, used to thicken liquid to prevent it from settling to the bottom quickly Common sugar, added to medicines as a sweetening agent 1 True discrepancies (shortage/loss) 2 PPE mask N95 3 Features of C-SEC 4 Auxillary label for methadone 5 Methadone for pain 6 Waste management 7 Effects of methadone 8 Take Home doses 9 Maintenance of C-PEC 10 Methadone 11 What is the appropirate measuring device for Methadone 12 Methadone labelling 13 PPE-2 pairs of chemotherapy gloves 14 Midazolam Syrup (Benzodiazepine) 15 C-PEC 16 C-SEC 17 Tetracycline Long-acting opioids act slower in the body; effects may last 24-36 hrs a day, can take weeks. Containment primary engineering control. Ventilated device to minimize exposure of workers & the environment Should be inspected every 6 months; all reusable equipment should be deactivated & cleaned. Equipment should not be removed. when deactivating/decontaminating C-PEC, spills, cleaning Dispensette: 0.5-5 mL, 0.5% accurate Relieve anxiety & produce sleepiness before surgery, produce amnesia, treats status epilepticus Containment secondary engineering control, the room which C-PEC is placed for compounding Level C Only MD can prescribe, for use in non-cancer pain, 6-8 hrs of pain relief Pharmaceutical products that are expired or no longer usable are considered pharmaceutical waste. Spills should complete an event report. It's important to filter after preparation; it may cause a fever. patient signs: doses will be kept locked, will not lend/sell, will take doses properly, return empty bottles, have regular urine tests. Measured using devices of 0.1 mL increments, only drugs authorized for drug addiction, effective 80% 12 air changes per hour, negative pressure -2.5 Pa, no windows Product name, total dose, drug has been diluted, drink the entire contents of bottle, date of ingestion Keep in refrigerator & May be fatal to child or adult Must be reported externally to Health Canada within 10 days Should be changed 3.5 hours of continuous work after each removal, if contamination has occurred.
Match the key terms descriptions to the Balance Sheet and Income Statement classifications