Relier Pairs pathophysiologyVersion en ligne inflammation, tissue repair, wound healing par angelina 1 tissue repair & wound healing 2 immune response 3 rubor 4 dolor 5 calor 6 tumor 7 functio laesa 8 inflammation reaction pain innate & adaptive loss of function swelling regeneration & replacement vascular & cellular response redness heat 1 leukotrienes action 2 histamine source 3 leukotrienes source 4 histamine action 5 complement protein action 6 prostaglandins source 7 complement proteins source 8 prostagliandins action 9 cytokines source 10 cytokines action vasodialation & increased vascular permeability pain, fever, vasodialation coordinate immune response, promote inflamation recruit leukocytes, bronchoconstriction leukocytes, mast cells damaged tissues, leukocytes liver, plamsa proteins mast cells, basophils attract immune cells, destrroy pathogens macrophages, t cells 1 innate immunity 2 purulent or suppuratice exudate 3 serous exudate 4 hemorrhagic exudates 5 serosanguineous 6 adaptive 7 assessing wound exudate Contain pus; composed of degraded white blood cells, proteins, and tissue debris Nonspecific, immediate defense (e.g., neutrophils, macrophages, barriers). clear/ pale yellow Result from plasma entering the inflammatory site bright red watery damage to blood vessels or when there is significant leakage of red cells from the capillaries light pink 1.color 2. amount 3. smell 4. culture/swab if any of the above are abnormal Specific, learned response involving lymphocytes and memory. 1 stable body cells 2 healing secondary 3 granulomatous inflammation ex 4 healing primary 5 permanant body cells 6 acute inflammation define 7 granulomatous inflammation define 8 labile body cells 9 acute inflamation ex 10 chronic inflammation ex 11 Chronic inflamation define relatively short duration; nonspecific early response to injury Aimed primarily at removing the injurious agent and limiting tissue damage small, clean wound with appoximated edges Continue to divide and replicate throughout life, replacing cells that are continually being destroyed. Ex. skin cells, GI intestinal lining Cannot undergo mitotic division Ex. neurons and cardiac cells copd Normally stop dividing when growth ceases but can regenerate if injured. Ex. hepatocytes (liver cells), lymphocytes (a type of white blood cell) a distinctive form of chronic inflammation characterized by the formation of granulomas — small, organized collections of macrophages great loss of tissue with contamination, wounds heal from the bottom up. flu A recurrent or progressive acute inflammatory process or a low-grade smoldering response that fails to evoke an acute response splinter, tuberculosis 1 proliferative phase 2 maturational phase 3 inflammatory phase 1 year The final phase, focused on strengthening and remodeling of the repaired tissue. 4-24 days Focuses on tissue regeneration and building new structures Focuses on tissue regeneration and building new structures fibroblast 1-6 days Goals to stop bleeding, remove debris and prepare for healing via platelet aggregation and vasodilation 1 Immunodeficiency Disorders secondary 2 Graft Versus Host Disease 3 type 2 hypersensitivity 4 transplant rejection chronic 5 type1 hypersensitivity 6 type 3 hypersensitivity 7 Immunodeficiency Disorders primary 8 type 1 diabetes 9 type 4 hypersensitivity 10 graves disease 11 Rheumatoid arthritis 12 transplant rejection acute 13 SLE "lupus" 14 Transplant Rejection hyperacute •Progressive organ failure •Hypertension (kidney) •Shortness of breath (lung) joint swelling, morning stiffness •Recurrent infections •Severe infections from common organisms •Failure to thrive (in infants) •Frequent infections •Opportunistic infections (Pneumocystis, Candida) •Weight loss •Fever, night sweats •Low CD4 count •Itching, urticaria (hives) •Rhinorrhea, sneezing (hay fever) •Bronchoconstriction, wheezing (asthma) •Hypotension, airway swelling (anaphylaxis) •Fever •Organ dysfunction (e.g., rising creatinine in kidney transplant) polyuria, polydipsia, weight loss tachycardia, heat intolerance, weight loss •Joint pain •Rash •Proteinuria/kidney involvement •Vasculitis •Features of SLE (fatigue, butterfly rash) •Hemolysis (jaundice, pallor, fatigue) •Fever/chills during transfusion reaction •Newborn hemolytic disease (Rh incompatibility) •Organ turns mottled, cyanotic •Immediate graft failure •Skin: rash, peeling •Liver: jaundice, elevated LFTs •GI: diarrhea, abdominal pain fatigue, joint pain, butterfly rash •Redness, itching, blistering (contact dermatitis) •Induration at TB skin test site
