PGx Week 12 Practice Quiz: HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1

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Medications impacted by polymorphisms in HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1, and their associated toxicities.

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Sophia

United States

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PGx Week 12 Practice Quiz: HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1Version en ligne Medications impacted by polymorphisms in HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1, and their associated toxicities. par Sophia 1 Which of the following medications are impacted by HLA-B15:02 polymorphisms? Select all that apply. Choose one or more answers a Abacavir b Allopurinol c Carbamazepine d Phenytoin 2 Polymorphisms in which of the following alleles can impact how a patient tolerates carbamazepine? Select all that apply. Choose one or more answers a HLA-B15:02 b HLA-A31:01 c HLA-B57:01 d HLA-B58:01 3 A 35-year-old patient is being evaluated for initiation of abacavir as part of antiretroviral therapy. HLA genotyping results are as follows: HLA-A: 31:01 / Y HLA-B: 15:02 / X, 57:01 / *57:01 What is the most appropriate recommendation regarding abacavir therapy for this patient? a Start abacavir as planned; the patient can safely receive it. b Start abacavir at a 25% increased dose to ensure proper therapeutic effect. c Do not start abacavir; choose an alternative agent due to risk of hypersensitivity reaction. d Start abacavir at a 50% reduced dose to minimize risk of hypersensitivity reaction. 4 Which of the following anesthetics is safe to use in a patient who tests positive for inherited autosomal dominant pattern for both RYR1 and CACNA1S ("MHS causative" variants)? a rocuronium b succinylcholine c halothane d methoxyflurane 5 Which of the following medications do NOT have to be avoided in patients with G6PD deficiency? a dapsone b nitrofurantoin c rasburicase d gentamicin 6 Which of the following statements regarding MT-RNR1 and aminoglycosides is FALSE? a nephrotoxicity is a known side effect of aminoglycosides b aminoglycoside-induced hearing loss is permanent c aminoglycoside-induced hearing loss occurs gradually after repeated aminoglycoside doses d variants in MT-RNR1 predispose individuals to aminoglycoside-induced hearing loss

PGx Week 12 Practice Quiz: HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1Version en ligne

Medications impacted by polymorphisms in HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1, and their associated toxicities.

par Sophia

Which of the following medications are impacted by HLA-B*15:02 polymorphisms? Select all that apply.

Choose one or more answers

Abacavir

Allopurinol

Carbamazepine

Phenytoin

Polymorphisms in which of the following alleles can impact how a patient tolerates carbamazepine? Select all that apply.

Choose one or more answers

HLA-B*15:02

HLA-A*31:01

HLA-B*57:01

HLA-B*58:01

A 35-year-old patient is being evaluated for initiation of abacavir as part of antiretroviral therapy. HLA genotyping results are as follows: HLA-A: 31:01 / Y HLA-B: 15:02 / X, 57:01 / 57:01 What is the most appropriate recommendation regarding abacavir therapy for this patient?

Start abacavir as planned; the patient can safely receive it.

Start abacavir at a 25% increased dose to ensure proper therapeutic effect.

Do not start abacavir; choose an alternative agent due to risk of hypersensitivity reaction.

Start abacavir at a 50% reduced dose to minimize risk of hypersensitivity reaction.

Which of the following anesthetics is safe to use in a patient who tests positive for inherited autosomal dominant pattern for both RYR1 and CACNA1S ("MHS causative" variants)?

rocuronium

succinylcholine

halothane

methoxyflurane

Which of the following medications do NOT have to be avoided in patients with G6PD deficiency?

dapsone

nitrofurantoin

rasburicase

gentamicin

Which of the following statements regarding MT-RNR1 and aminoglycosides is FALSE?

nephrotoxicity is a known side effect of aminoglycosides

aminoglycoside-induced hearing loss is permanent

aminoglycoside-induced hearing loss occurs gradually after repeated aminoglycoside doses

variants in MT-RNR1 predispose individuals to aminoglycoside-induced hearing loss

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PGx Week 12 Practice Quiz: HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1

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PGx Week 12 Practice Quiz: HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1Version en ligne

par Sophia

Which of the following medications are impacted by HLA-B*15:02 polymorphisms? Select all that apply.

Choose one or more answers

Polymorphisms in which of the following alleles can impact how a patient tolerates carbamazepine? Select all that apply.

Choose one or more answers

A 35-year-old patient is being evaluated for initiation of abacavir as part of antiretroviral therapy. HLA genotyping results are as follows: HLA-A: 31:01 / Y HLA-B: 15:02 / X, 57:01 / 57:01 What is the most appropriate recommendation regarding abacavir therapy for this patient?

Which of the following anesthetics is safe to use in a patient who tests positive for inherited autosomal dominant pattern for both RYR1 and CACNA1S ("MHS causative" variants)?

Which of the following medications do NOT have to be avoided in patients with G6PD deficiency?

Which of the following statements regarding MT-RNR1 and aminoglycosides is FALSE?

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PGx Week 12 Practice Quiz: HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1

Test

À propos de cette activité

Créé par

Téléchargez la version pour jouer sur papier

Top Jeux

Test

Spanish Alphabet Listening

Test

Photosynthesis vs Cellular Respiration - Practice Quiz

Test

Tissues - Practice Quiz

Test

Practice Quiz - Punnett Square, Variation, and Mutations

Test

UPS 5 Seeing Habits Quiz

PGx Week 12 Practice Quiz: HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1Version en ligne

par Sophia

Which of the following medications are impacted by HLA-B*15:02 polymorphisms? Select all that apply.

Polymorphisms in which of the following alleles can impact how a patient tolerates carbamazepine? Select all that apply.

A 35-year-old patient is being evaluated for initiation of abacavir as part of antiretroviral therapy. HLA genotyping results are as follows: HLA-A: *31:01 / *Y HLA-B: *15:02 / *X, *57:01 / *57:01 What is the most appropriate recommendation regarding abacavir therapy for this patient?

Which of the following anesthetics is safe to use in a patient who tests positive for inherited autosomal dominant pattern for both RYR1 and CACNA1S ("MHS causative" variants)?

Which of the following medications do NOT have to be avoided in patients with G6PD deficiency?

Which of the following statements regarding MT-RNR1 and aminoglycosides is FALSE?

A 35-year-old patient is being evaluated for initiation of abacavir as part of antiretroviral therapy. HLA genotyping results are as follows: HLA-A: 31:01 / Y HLA-B: 15:02 / X, 57:01 / 57:01 What is the most appropriate recommendation regarding abacavir therapy for this patient?