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Chapter 25 Cholinergic Drugs

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Chapter 25 Cholinergic Drugs
 

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Chapter 25 Cholinergic DrugsVersion en ligne

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par Breanna Spears
1

muscarinic nicotinic

There are two types of repetors in the parasympathetic nervous branch : receptors ( which stimulates smooth muscle ) and receptors ( which stimulates skeletal muscle ) .

2

parasympathomimetic synergistic Cholinergic acetylcholinesterase adrenergic

drugs mimic the activity of the parasympathetic nervous system . They are also called drug s

3

ACh AChE Acetylcholinesterase

( ) is an enzyme that can inactivate the neurotransmitter , thereby preventing the nerve synapse from continuing the nerve impulse .

4

Acetylcholine acetylcholinesterse norepinephrine ACh

( ) is the neurotransmission substance that carries nerve impulses across the parasympathetic branch of the autonomic nervous system .

5

myasthenia gravis lewy body Alzheimer dementia colon

This interruption in neurotransmission can diminish cognitive function , which is seen in illnesses such as disease .

6

anticholinesterase cholinergic inhibitors dopamine anticolontise acetylcholinsterase drugs

Drugs that inhibit the enzyme AChE are called or .

7

direct reproductive circulatory cardiac digestion respiratory cholinergics elimination vision acting

Drugs acting on the sympathetic nervous system more prominently impact the , , or systems . Cholinergic drugs that act on the parasympathetic nervous system more prominently impact , , and the system . Drugs like ACh are called - .

8

stimulants acting muscle cholinergics indirect anticholinesterase ACh AChe

Cholinergic drugs that prolong the activity of by inhibiting the release of are called - or . This occurs when there's a lack of ACh being released at the nerve endings of the PN S

9

glaucoma immunotherapy gravis myasthenia

An example of indirect action is the use of cholinergic drugs to treat , a disease that involves rapid fatigue of skeletal muscles . Primary treatment of this disease is accomplished with .

10

indirect-acting cholinergics neurogenic bladder miosis cholinergics direct urinary retention acting micturition

Drugs like ACh are called - . An example of cholinergic influence is on the act of ( voiding of urine ) .

11

acting Urinary retention fluid retention involuntary constricting retention cholinergic contraction parasympathetic urinary volunty direct relaxing involuntary indirect-acting cholinergics

Micturition is both a and an act . The branch of the autonomic nervous system party controls the ( ) process of micturition by the detrusor muscle and the bladder sphincter . results when micturition is impaired . Treatment of with - drugs causes of the bladder smooth muscles and passage of urine .

12

miosis mitosis acting indirect direct-acting cholinergic glaucoma anticholinesterase muscle stimulant cholinergic micturition

Treatment of with an - drugs produces ( constriction of the iris ) .

13

Acytylcholinesterase cholinergic Norepinephrine Acetylcholine Dopamine

Which of the following is the substance responsible for transmission of nerve impulses across the parasympathetic nervous system ?

14

gravis Myasthenia fluid retention Urinary Neurogenic relaxed abdominal cramping retention gastroinintestinal issues Cardiac arrythmias

Major uses of the cholinergic drugs are in the treatment of the following :
, bladder , and .

15

tissue perfusion respiratory distress Nausea diarrhea salivation flushing urinary retention weakness dizziness cardiac muscle arrythmias myasthenia gravis

General adverse reactions include the following :
, , abdominal cramping , , of the skin , , and .

16

peptic asthma hyperthyroidism coronary iritis atropine corneal hypersensitivity glaucoma genitourinary GI Bethanol

These drugs are contraindicated in clients with known to the drugs , , ulcers disease , artery disease , and . is contraindicated in those with mechanical obstruction of the or tracts . Clients with secondary , , abrasion , or any actue inflammatory disease of the eye should not use the ophthalamic cholinergic preparations .

17

pregnancy E megacolon arrhythmias lactation C coronary cardiac tachycardia bradycardia hypertension D hypotension

These drugs are used cautiously in clients with , epilepsy , , , recent occlusion , and . The safety of the drugs have NOT been established for use during ( pregnancy category ) , , or children

18

Pyridostigmine amplifies cholinergic anticholinergic Bethanechol agonizes antidote eliminator synergistic atropine Zyban acetylcholinesterase anticholinergic antagonizes

When drugs are administered with the other cholinergics , there is a ( the effect is greater than that of each of the two drugs separately ) effect of the drugs and greater risk for toxicity . Concurrent use of more than one drug the effects of cholinergic drugs . Because drugs can have this additive effect , is the drug used as an for overdose of cholinergic drugs .

19

Zyban dry mouth salivation muscle Cholinergic weakness atropine constipation nausea diarrhea corticosteriods

crisis ( cholinergic drug toxicity ) symptoms include severe abdominal cramping , , excessive , , rigidity and spasm , and clenching of the jaw . In case of drug overdose , an antidote such as is administered .

20

absence increased gravis presence before between client's myasthenia decreased response

For a client with , you have to assess the client for the or of the symptoms before each drug dose ( extreme fatigue , drooping eyelids , muscle weakness , inability to chew and swallow , etc ) . Carry out these assessments drug doses as well as immediately drug administered . Assessment is important because the dosage ferequently is or early in therapy , depending on the .

21

20-30 15 buccal 30 30-60 5 subcutaneous IV 90 oral

Voiding usually occurs in - min after drug administration and - min after administration

22

time-released 1-2 2 release 3-4 Sustained myasthenia 4 gravis

Oral drug administration is typically the route used to manage symptoms of . Clients with severe symptoms of the disease require the drug every - hr , even during the night . - tablets are available that alow less frequent dosing and help the client have longer undisturbed periods during the night .

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