Outline the in vitro coagulation cascades

À propos de cette activité

intrinsic, extrinsic, and common pathways

Créé par

Gawain

United States

Téléchargez la version pour jouer sur papier

Top 10 résultats

Il n'y a toujours pas de résultats pour ce jeu. Soyez le premier à apparaître dans le classement! Connectez-vous pour vous identifier.

Créez votre propre jeu gratuite à partir de notre créateur de jeu

Affrontez vos amis pour voir qui obtient le meilleur score dans ce jeu

Créer un défi


Compléter Outline the in vitro coagulation cascadesVersion en ligne intrinsic, extrinsic, and common pathways par Gawain 1 Xa XIa in XI Xa IXa XII IXa IX VIIIa in XII aPTT XIIa X vitro vivo XIIa XIa Intrinsic Pathway ( Contact Activation Pathway ) Triggered by exposure to negatively charged surfaces Requires phospholipid from platelet membrane Factors involved : Factor ? Activated by contact with foreign surfaces activates Factor ? activates Factor ? + cofactor ( activated by thrombin ) form tenase complex Tenase complex activates Factor ? activates common pathway * Factor is not important ( real - life clotting ) , but it is critical ( lab tests like ) 2 Time VII IX Xa TF X PT IXa Prothrombin VIIa Xa TF Extrinsic Pathway ( Tissue Factor Pathway ) Triggered by tissue injury and exposure of tissue factor ( Factor III ) Phospholipid source = damaged endothelium ( tissue factor ) Factors involved : Tissue Factor ( III ) binds with Factor ? ? VIIa complex activates Factor ? ? common pathway ? VIIa complex also activates Factor ? Initiates coagulation quickly and bypasses the contact phase Tested by ( ) 3 Va Thrombin Xa II V Fibrin XIII IIa Prothrombin XIIIa Thrombin VIII Fibrinogen Common Pathway Starts with activation of Factor X ? Xa Factors involved : + cofactor = Prothrombinase complex Converts ( ) ? ( ) : Converts ? monomers Activates Factor ? ? crosslinks fibrin = stable clot Activates Factors and ( positive feedback ) 4 factor II IX VII tissue VIII X XI III XII V State what factors belong to the intrinsic , extrinsic , and common pathways Intrinsic / Contact System Prekallikrein ( PK ) , high - molecular - weight kininogen ( HK ) , , , , and Extrinsic and ( ) Common pathway , , , I 5 XII kininogen HK Prekallikrein BK BK PK molecular weight high Bradykinin Describe contact activation and list the substances involved Contact activation pathway : there is a substance in the blood initiating procoagulant molecules . Activated by negatively charged surfaces ( i . e Endothelial cells , leukocytes , bacteria , thrombocytes ) ( ) , - - ( ) , activated by negatively charged substances ? production of ( ) binds to cell membrane receptors ? starts signaling pathways ? increases inflammatory processes Does not contribute to normal clot formation in vivo but does contribute to inflammation , blood pressure regulation and fibrinolysi s

Compléter

Outline the in vitro coagulation cascadesVersion en ligne

intrinsic, extrinsic, and common pathways

Xa XIa in XI Xa IXa XII IXa IX VIIIa in XII aPTT XIIa X vitro vivo XIIa XIa

Intrinsic Pathway ( Contact Activation Pathway )
Triggered by exposure to negatively charged surfaces
Requires phospholipid from platelet membrane
Factors involved :
Factor ?
Activated by contact with foreign surfaces
activates Factor ?
activates Factor ?
+ cofactor ( activated by thrombin ) form tenase complex
Tenase complex activates Factor ?
activates common pathway
* Factor is not important ( real - life clotting ) , but it is critical ( lab tests like )

Time VII IX Xa TF X PT IXa Prothrombin VIIa Xa TF

Extrinsic Pathway ( Tissue Factor Pathway )
Triggered by tissue injury and exposure of tissue factor ( Factor III )
Phospholipid source = damaged endothelium ( tissue factor )
Factors involved :
Tissue Factor ( III ) binds with Factor ?
? VIIa complex activates Factor ?
? common pathway
? VIIa complex also activates Factor ?
Initiates coagulation quickly and bypasses the contact phase
Tested by ( )

Va Thrombin Xa II V Fibrin XIII IIa Prothrombin XIIIa Thrombin VIII Fibrinogen

Common Pathway
Starts with activation of Factor X ? Xa
Factors involved :
+ cofactor = Prothrombinase complex
Converts ( ) ? ( )
:
Converts ? monomers
Activates Factor ? ? crosslinks fibrin = stable clot
Activates Factors and ( positive feedback )

factor II IX VII tissue VIII X XI III XII V

State what factors belong to the intrinsic , extrinsic , and common pathways
Intrinsic / Contact System
Prekallikrein ( PK ) , high - molecular - weight kininogen ( HK ) , , , , and
Extrinsic
and ( )
Common pathway
, , , I

XII kininogen HK Prekallikrein BK BK PK molecular weight high Bradykinin

Describe contact activation and list the substances involved
Contact activation pathway : there is a substance in the blood initiating procoagulant molecules .
Activated by negatively charged surfaces ( i . e Endothelial cells , leukocytes , bacteria , thrombocytes )
( ) , - - ( ) , activated by negatively charged substances ? production of ( )
binds to cell membrane receptors ? starts signaling pathways ? increases inflammatory processes
Does not contribute to normal clot formation in vivo but does contribute to inflammation , blood pressure regulation and fibrinolysi s

Vous pouvez intégrer le jeu dans un LMS compatible avec LTI 1.1 ou LTI 1.3 comme Canvas, Moodle ou Blackboard. Les scores seront ainsi automatiquement enregistrés dans le carnet de notes de la plateforme.

Outline the in vitro coagulation cascades

Compléter

À propos de cette activité

Créé par

Téléchargez la version pour jouer sur papier

Top Jeux

Compléter

FFA Creed Paragraph #2

Compléter

FFA Creed Paragraph 3

Compléter

The Preamble

Compléter

COMPLETE THE LYRICS OF SONG

Compléter

Anatomy quiz

Compléter

Outline the in vitro coagulation cascadesVersion en ligne

par Gawain

Xa XIa in XI Xa IXa XII IXa IX VIIIa in XII aPTT XIIa X vitro vivo XIIa XIa

Time VII IX Xa TF X PT IXa Prothrombin VIIa Xa TF

Va Thrombin Xa II V Fibrin XIII IIa Prothrombin XIIIa Thrombin VIII Fibrinogen

factor II IX VII tissue VIII X XI III XII V

XII kininogen HK Prekallikrein BK BK PK molecular weight high Bradykinin

		%
	Anonyme	%
		%
		%