Relier Pairs Chapter 17 Innate, nonspecific Host DefensesVersion en ligne chapter 17 vocabulary par Janet Marticorena 1 Adaptive response 2 purpose of immune system 3 Plasma contains: 4 Immunity 5 Innate response 6 Chemical barriers 7 Physical barriers 8 Serum contains: skin, mucus membranes, cilia, flushing, reflexes, normal flora/ microbiome complement proteins, antibodies, molecules not related to defense b cells, t cells, chemical components clotting factors, complement proteins, antibodies barriers, eliminators, chemical components a state of having sufficient biological defenses to avoid infection, disease or other unwanted biological invasion stomach acid, lysozyme, low ph from ear wax and fatty acids surveillance of the body, recognition of foreign invaders and material, destruction of foregin invaders 1 Neutrophils 2 PRR 3 Monocyte 4 Microglial 5 PAMPs 6 Alveolar macrophage 7 Cytokines pattern recognition receptor, receptors on phagocytic cells that recognize PAMPs, Toll-like receptors in the blood in the lungs pathogen-associated molecular patterns, things on the exterior part of pathogen that cause a response in the brain most abundant white blood cell in the blood, engulf and destroy bacteria, uses NETS, make pus formation signaling molecules secreated by many different immune cells 1 1- injured/infected cells secrete chemical signals into the blood, what happend next? 2 2- 3 3 leukocytes in the blood respond to chemical attractants released by pathogens and chemical signal from nearby injured cells the leukocytes squeeze between the cells of the capillary wall as they follow the chemical signals to where they are most concentrated neutrophils releases cytotoxic chemicals from granules into tissue 1 endogenous pyrogens 2 exogenous pyrogens 3 Swelling 4 Redness 5 Warmth 6 Pain pathogen trigger or something else trigger it (tumor) because all the extra volume you trigger it, our own cells trigger it (rubor) due to lots of blood to the area (calor) because the blood comes from the core (dolor) the nerves become pinched 1 Complement system 2 3 ways to activate complement system 3 Natural killer cells 4 3 outcomes of complement activation cell recognizes MHC1 on a healthy cell and does not kill it but on infected cell does not present MHC1 it kills it a series of proteins in the blood that complements other immune functions classical, alternative, mannose-lectin pathways stimulation of inflammation, opsonization and membrane attack complex
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