Relier Pairs Cholesterol pharmacologyVersion en ligne Cholesterol pharmacology par Ashleigh Pell 1 statin indication 2 statin warning 3 with less cholesterol synthesis, what does the liver do? 4 statin side effects 5 standard statin 6 What does the enzyme HMG-CoA do? 7 most potent statin 8 statin with less drug interactions 9 What statins do, and where high lipids / LDL myalgia/headache/GI symptoms simvastatin inhibit HMG-CoA reductase in the liver increases hepatic synthesis of cholesterol increases the uptake of low-density lipoprotein (LDL) from the blood pravastatin atorvastatin Grapefruit inhibits cytochrome P450, increasing statin bioavailability. 1 ezetimisbe side effect 2 Alirocumab side effects 3 alirocumab indication 4 fenofibrate activates 5 Fenofibrate indication 6 fenofibrate side effects 7 Alirocumab inhibits 8 ezetimibe inhibits 9 fenofibrate caution 10 fenofibrate contra-indication 11 fenofibrate causes lipolysis because intestinal cholesterol absorption inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors GI upset/vomiting nuclear receptor PPARα which begins gene transcription and translation flu-like symptoms PPARα's genes code for peroxisomes which participate in lipolysis familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective gall bladder disease, pancreatitis high serum triglycerides weakness/GI upset/headaches myotoxicity if improper dose or renal impairment.
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