Relier Pairs Cholesterol pharmacologyVersion en ligne Cholesterol pharmacology par Ashleigh Pell 1 What does the enzyme HMG-CoA do? 2 standard statin 3 statin side effects 4 most potent statin 5 statin indication 6 statin with less drug interactions 7 What statins do, and where 8 with less cholesterol synthesis, what does the liver do? 9 statin warning atorvastatin Grapefruit inhibits cytochrome P450, increasing statin bioavailability. inhibit HMG-CoA reductase in the liver increases the uptake of low-density lipoprotein (LDL) from the blood pravastatin myalgia/headache/GI symptoms simvastatin high lipids / LDL increases hepatic synthesis of cholesterol 1 Alirocumab side effects 2 fenofibrate contra-indication 3 ezetimibe inhibits 4 ezetimisbe side effect 5 fenofibrate activates 6 alirocumab indication 7 fenofibrate causes lipolysis because 8 fenofibrate caution 9 fenofibrate side effects 10 Alirocumab inhibits 11 Fenofibrate indication high serum triglycerides inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors GI upset/vomiting flu-like symptoms weakness/GI upset/headaches myotoxicity if improper dose or renal impairment. nuclear receptor PPARα which begins gene transcription and translation gall bladder disease, pancreatitis familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective PPARα's genes code for peroxisomes which participate in lipolysis intestinal cholesterol absorption
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