Relier Pairs Cholesterol pharmacologyVersion en ligne Cholesterol pharmacology par Ashleigh Pell 1 statin indication 2 statin side effects 3 What statins do, and where 4 standard statin 5 most potent statin 6 statin warning 7 What does the enzyme HMG-CoA do? 8 with less cholesterol synthesis, what does the liver do? 9 statin with less drug interactions Grapefruit inhibits cytochrome P450, increasing statin bioavailability. myalgia/headache/GI symptoms pravastatin increases the uptake of low-density lipoprotein (LDL) from the blood inhibit HMG-CoA reductase in the liver increases hepatic synthesis of cholesterol atorvastatin high lipids / LDL simvastatin 1 alirocumab indication 2 Alirocumab side effects 3 Alirocumab inhibits 4 fenofibrate contra-indication 5 ezetimibe inhibits 6 ezetimisbe side effect 7 fenofibrate caution 8 fenofibrate causes lipolysis because 9 Fenofibrate indication 10 fenofibrate side effects 11 fenofibrate activates nuclear receptor PPARα which begins gene transcription and translation intestinal cholesterol absorption myotoxicity if improper dose or renal impairment. flu-like symptoms high serum triglycerides PPARα's genes code for peroxisomes which participate in lipolysis inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors GI upset/vomiting weakness/GI upset/headaches gall bladder disease, pancreatitis familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective
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