Relier Pairs Cholesterol pharmacologyVersion en ligne Cholesterol pharmacology par Ashleigh Pell 1 What statins do, and where 2 statin warning 3 statin indication 4 What does the enzyme HMG-CoA do? 5 most potent statin 6 statin side effects 7 statin with less drug interactions 8 standard statin 9 with less cholesterol synthesis, what does the liver do? myalgia/headache/GI symptoms atorvastatin Grapefruit inhibits cytochrome P450, increasing statin bioavailability. simvastatin increases the uptake of low-density lipoprotein (LDL) from the blood pravastatin increases hepatic synthesis of cholesterol high lipids / LDL inhibit HMG-CoA reductase in the liver 1 ezetimisbe side effect 2 Alirocumab inhibits 3 fenofibrate causes lipolysis because 4 fenofibrate side effects 5 Fenofibrate indication 6 alirocumab indication 7 fenofibrate contra-indication 8 fenofibrate caution 9 ezetimibe inhibits 10 Alirocumab side effects 11 fenofibrate activates familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective high serum triglycerides nuclear receptor PPARα which begins gene transcription and translation intestinal cholesterol absorption gall bladder disease, pancreatitis GI upset/vomiting myotoxicity if improper dose or renal impairment. inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors PPARα's genes code for peroxisomes which participate in lipolysis weakness/GI upset/headaches flu-like symptoms
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