Relier Pairs Cholesterol pharmacologyVersion en ligne Cholesterol pharmacology par Ashleigh Pell 1 statin indication 2 What does the enzyme HMG-CoA do? 3 with less cholesterol synthesis, what does the liver do? 4 most potent statin 5 statin with less drug interactions 6 statin warning 7 statin side effects 8 standard statin 9 What statins do, and where simvastatin atorvastatin pravastatin inhibit HMG-CoA reductase in the liver myalgia/headache/GI symptoms Grapefruit inhibits cytochrome P450, increasing statin bioavailability. increases the uptake of low-density lipoprotein (LDL) from the blood high lipids / LDL increases hepatic synthesis of cholesterol 1 ezetimibe inhibits 2 fenofibrate causes lipolysis because 3 ezetimisbe side effect 4 fenofibrate contra-indication 5 fenofibrate caution 6 alirocumab indication 7 fenofibrate activates 8 fenofibrate side effects 9 Alirocumab inhibits 10 Fenofibrate indication 11 Alirocumab side effects nuclear receptor PPARα which begins gene transcription and translation flu-like symptoms inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors intestinal cholesterol absorption GI upset/vomiting gall bladder disease, pancreatitis PPARα's genes code for peroxisomes which participate in lipolysis weakness/GI upset/headaches familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective myotoxicity if improper dose or renal impairment. high serum triglycerides
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