Relier Pairs Cholesterol pharmacologyVersion en ligne Cholesterol pharmacology par Ashleigh Pell 1 statin side effects 2 statin warning 3 What statins do, and where 4 with less cholesterol synthesis, what does the liver do? 5 statin with less drug interactions 6 standard statin 7 What does the enzyme HMG-CoA do? 8 most potent statin 9 statin indication atorvastatin inhibit HMG-CoA reductase in the liver simvastatin Grapefruit inhibits cytochrome P450, increasing statin bioavailability. myalgia/headache/GI symptoms increases hepatic synthesis of cholesterol high lipids / LDL pravastatin increases the uptake of low-density lipoprotein (LDL) from the blood 1 fenofibrate side effects 2 ezetimisbe side effect 3 Alirocumab side effects 4 ezetimibe inhibits 5 fenofibrate activates 6 fenofibrate caution 7 fenofibrate contra-indication 8 Fenofibrate indication 9 alirocumab indication 10 Alirocumab inhibits 11 fenofibrate causes lipolysis because weakness/GI upset/headaches myotoxicity if improper dose or renal impairment. familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective PPARα's genes code for peroxisomes which participate in lipolysis gall bladder disease, pancreatitis high serum triglycerides inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors nuclear receptor PPARα which begins gene transcription and translation flu-like symptoms intestinal cholesterol absorption GI upset/vomiting
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