Relier Pairs Cholesterol pharmacologyVersion en ligne Cholesterol pharmacology par Ashleigh Pell 1 statin with less drug interactions 2 most potent statin 3 with less cholesterol synthesis, what does the liver do? 4 statin side effects 5 statin warning 6 What statins do, and where 7 What does the enzyme HMG-CoA do? 8 statin indication 9 standard statin pravastatin high lipids / LDL increases the uptake of low-density lipoprotein (LDL) from the blood myalgia/headache/GI symptoms atorvastatin Grapefruit inhibits cytochrome P450, increasing statin bioavailability. inhibit HMG-CoA reductase in the liver increases hepatic synthesis of cholesterol simvastatin 1 Fenofibrate indication 2 ezetimibe inhibits 3 fenofibrate side effects 4 Alirocumab inhibits 5 Alirocumab side effects 6 fenofibrate causes lipolysis because 7 fenofibrate caution 8 fenofibrate activates 9 fenofibrate contra-indication 10 ezetimisbe side effect 11 alirocumab indication nuclear receptor PPARα which begins gene transcription and translation inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors myotoxicity if improper dose or renal impairment. flu-like symptoms weakness/GI upset/headaches gall bladder disease, pancreatitis familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective intestinal cholesterol absorption GI upset/vomiting PPARα's genes code for peroxisomes which participate in lipolysis high serum triglycerides
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