Infection, Tumor imaging, and Therapy study quiz (4/4)

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Joshua Liberty

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Infection, Tumor imaging, and Therapy study quiz (4/4)Version en ligne Slides 31-42 par Joshua Liberty 1 Fluciclovine is indicated for? a Prostate cancer b Lung cancer c Melanoma d Epilepsy 2 Dose for Fluciclovine a 9 mCi b 20 mCi c 10 mCi d 12 mCi 3 What is the patient prep for a Fluciclovine study a Take potassium chloride to block thyroid uptake b Avoid significant exercise for at least one day prior c NPO at least four hours d NPO at least four hours and Avoid significant exercise for at least one day prior e Check blood sugar f NPO at least four hours and Check blood sugar 4 Fluciclovine study requires both arms down by the side. a True b False 5 How soon do we start the study and how long does it last for Fluciclovine. a 3-5 minutes; 10-20 minutes b 60 minutes; 20-30 minutes c 50 minutes; 10-15 minutes d 3-5 minutes; 5-10 minutes 6 What is the critical organ of Fluciclovine? a Pancreas b Kidneys c Bladder d Prostate e Heart f Stomach 7 What is the MOL of Fluciclovine? a Targets the CD20 antigen on surface of normal/malignant B lymphocytes b Upon binding to somatostatin receptor expressing cells, including malignant somatostatin receptor positive tumors. c A synthetic amino acid transported across mammalian cell membranes by amino acid transporters d Binds to cells that express PSMA, including malignant prostate cancer cells, which usually overexpress PSMA 8 Which has the highest normal distribution of Fluciclovine? a Liver b Kidneys c Pancreas d Lung e Red bone marrow f Myocardium 9 Where does Fluciclovine abnormally accumulate? a Salivary glands b Small focal lesions uptake greater than blood pool c Large lesions uptake greater than or equal to bone marrow d None of these e All of these f Small focal lesions uptake greater than blood pool and Large lesions uptake greater than or equal to bone marrow 10 Fluciclovine is specific for Prostate cancer? a True b False 11 Iobengaune I-131 therapy is indicated for ? a Treatment of Castration resistant prostate cancer in adults. b Treatment of Thyroid whole body metastatic cancer c Treatment of Hyperactive Liver Mets d Treatment of adult/pediatric patients 12 years and older with iobenguane scan positive, unresectable, locally advanced or metastatic 12 How often should a patient take inorganic iodine to block their thyroid before and after treatment? a 24 hours before; 7 days after each treatment b 24 hours before; 10 days after each treatment c 4 hours before; 10 days after each treatment d 12 hours before; 6 days after each treatment 13 Patients need to drink at least 500 mL extra fluid each day and before/after each treatment to help reduce exposure to the bladder. a True b False 14 Antimetics are drugs that reduce vomiting and nausea. a True b False 15 The dose for Iobengaune I-131 is? and what weight does it correlate with? a >50 kg; 5 to 6 mCi b <50 kg; 0.1 mCi/kg c >50 kg; 1-4 mCi d <50 kg; 0.5 mCi/kg e <50 kg; 0.1 mCi/kg, >50 kg; 5 to 6 mCi f >50 kg;1-4 mCi, <50 kg; 0.5 mCi/kg 16 What kind of image positions do we need for Iobengaune I-131. a Anterior WB b Posterior WB c Anterior and Posterior WB d Anterior and Laterals WB e Posterior and Obliques WB 17 What is the Therapy dose for Iobengaune I-131? a >62.5 kg: 500 mCi b <62.5 kg: 500 mCi c >62.5 kg: 8 mCi/kg d <62.5 kg: 8 mCi/kg e >62.5 kg: 500 mCi, <62.5 kg: 8 mCi/kg f <62.5 kg: 500 mCi, >62.5 kg: 8 mCi/kg 18 What is the main concern for patients undergoing Iobengaune I-131 therapy? a Severe and prolonged myelosuppression b Grade 4 neutropenia c Grade 4 anemia d Febrile neutropenia e All of these f None of these 19 Which of these occurs for patients undergoing Iobengaune I-131 therapy at only 5% of the receiving population. a Severe and prolonged myelosuppression b Grade 4 neutropenia c Grade 4 anemia d Febrile neutropenia e All of these f None of these 20 Piflufolastat is specific to PMSA? a True b False 21 Who is a candidate for Piflufolastat? a With suspected Metastasis who are candidates for initial therapy b With suspected recurrence based on elevated serum prostate specific antigen (PSA) level c Patients with prostate already removed from surgery. d Patients with previous history of melanoma e With suspected Metastasis who are candidates for initial therapy and With suspected recurrence based on elevated serum prostate specific antigen (PSA) level 22 What is the dose for Piflufolastat? a 20 mCi b 4 mCi c 12 mCi d 9 mCi 23 How soon can imaging with Piflufolastat can occur? a 50 minutes b 60 minutes c 20 minutes d 2 hours 24 What is the scanning region for Piflufolastat? a Skull to thigh b Top of the skull to mid thigh c Whole body d Lower abdomen to mid thigh 25 Piflufolastat can have misinterpretation in a variety of tumor types. a True b False 26 Which of these is not a adverse reaction of Piflufolastat? a Headache b Dysgeusia c Fatigue d Nausea 27 Lesions should be considered suspicious if uptake is greater than _______ for Piflufolastat? a Greater then physiologic uptake in that tissue or greater than adjacent background if no physiologic uptake is expected. b Less then physiologic uptake in that tissue or less than adjacent background if no physiologic uptake is expected. c Greater than uptake in sites with known tumors d Greater in sites with uptake in greater concentration to surrounding tissue. 28 Tumors that do not express PSMA will still be visualized. a True b False 29 What is the MOL for Piflufolastat? a A synthetic amino acid transported across mammalian cell membranes by amino acid transporters b Binds to cells that express PSMA, including malignant prostate cancer cells, which usually overexpress PSMA c Upon binding to somatostatin receptor expressing cells, including malignant somatostatin receptor positive tumors. d Targets the CD20 antigen on surface of normal/malignant B lymphocytes 30 Lu-177 Pluvicto is used for patients before Adrogen therapy and taxane-based chemotherapy. a True b False 31 What is the Dose for PLUVICTO? How often is it given? a 200 mCi; every 6 weeks for up to 6 doses b 300 mCi; every 6 weeks for up to 5 doses c 200 mCi; every 4 weeks for up to 5 doses d 100 mCi; every 6 weeks for up to 6 doses 32 What is needed before each dose of PLUVICTO? a PSA Levels b Complete blood counts c Whole body scan d Adequate hydration 33 If patients blood work shows inadequate RBC, WBC , and platelets, then the dose should be? a Withheld b Reduced c Permanently discontinued d Increased e Withheld, Reduced, or Permanently discontinued 34 PLUVICTO can cause severe liver toxicity. a True b False 35 MOL of PLUVICTO a Binds to cells that express PSMA, including malignant prostate cancer cells, which usually overexpress PSMA b Targets the CD20 antigen on surface of normal/malignant B lymphocytes c Binds to PSMA, a transmembrane protein that is expressed in prostate cancer, including mCRPC d A synthetic amino acid transported across mammalian cell membranes by amino acid transporters 36 How long should patients receiving PLUVICTO isolate from pregnant women and children? a 14 days; 7 days b 7 days; 14 days c 5 days; 10 days d 6 days; 12 days Feedback 4 Arms up 8 Liver(14%), Pancreas(3%), Lung (7%), Red bone marrow( 12%), and Myocardium (4%). 10 Not specific, it may occur in other types of cancers and benign prostatic hypertrophy in primary prostate cancer. 13 At least 2 Liters 28 They will not be visualized 30 It is used after 34 Renal Toxicity

Infection, Tumor imaging, and Therapy study quiz (4/4)Version en ligne

Slides 31-42

par Joshua Liberty

Fluciclovine is indicated for?

Prostate cancer

Lung cancer

Melanoma

Epilepsy

Dose for Fluciclovine

9 mCi

20 mCi

10 mCi

12 mCi

What is the patient prep for a Fluciclovine study

Take potassium chloride to block thyroid uptake

Avoid significant exercise for at least one day prior

NPO at least four hours

NPO at least four hours and Avoid significant exercise for at least one day prior

Check blood sugar

NPO at least four hours and Check blood sugar

Fluciclovine study requires both arms down by the side.

True

False

How soon do we start the study and how long does it last for Fluciclovine.

3-5 minutes; 10-20 minutes

60 minutes; 20-30 minutes

50 minutes; 10-15 minutes

3-5 minutes; 5-10 minutes

What is the critical organ of Fluciclovine?

Pancreas

Kidneys

Bladder

Prostate

Heart

Stomach

What is the MOL of Fluciclovine?

Targets the CD20 antigen on surface of normal/malignant B lymphocytes

Upon binding to somatostatin receptor expressing cells, including malignant somatostatin receptor positive tumors.

A synthetic amino acid transported across mammalian cell membranes by amino acid transporters

Binds to cells that express PSMA, including malignant prostate cancer cells, which usually overexpress PSMA

Which has the highest normal distribution of Fluciclovine?

Liver

Kidneys

Pancreas

Lung

Red bone marrow

Myocardium

Where does Fluciclovine abnormally accumulate?

Salivary glands

Small focal lesions uptake greater than blood pool

Large lesions uptake greater than or equal to bone marrow

None of these

All of these

Small focal lesions uptake greater than blood pool and Large lesions uptake greater than or equal to bone marrow

Fluciclovine is specific for Prostate cancer?

True

False

Iobengaune I-131 therapy is indicated for ?

Treatment of Castration resistant prostate cancer in adults.

Treatment of Thyroid whole body metastatic cancer

Treatment of Hyperactive Liver Mets

Treatment of adult/pediatric patients 12 years and older with iobenguane scan positive, unresectable, locally advanced or metastatic

How often should a patient take inorganic iodine to block their thyroid before and after treatment?

24 hours before; 7 days after each treatment

24 hours before; 10 days after each treatment

4 hours before; 10 days after each treatment

12 hours before; 6 days after each treatment

Patients need to drink at least 500 mL extra fluid each day and before/after each treatment to help reduce exposure to the bladder.

True

False

Antimetics are drugs that reduce vomiting and nausea.

True

False

The dose for Iobengaune I-131 is? and what weight does it correlate with?

>50 kg; 5 to 6 mCi

<50 kg; 0.1 mCi/kg

>50 kg; 1-4 mCi

<50 kg; 0.5 mCi/kg

<50 kg; 0.1 mCi/kg, >50 kg; 5 to 6 mCi

>50 kg;1-4 mCi, <50 kg; 0.5 mCi/kg

What kind of image positions do we need for Iobengaune I-131.

Anterior WB

Posterior WB

Anterior and Posterior WB

Anterior and Laterals WB

Posterior and Obliques WB

What is the Therapy dose for Iobengaune I-131?

>62.5 kg: 500 mCi

<62.5 kg: 500 mCi

>62.5 kg: 8 mCi/kg

<62.5 kg: 8 mCi/kg

>62.5 kg: 500 mCi, <62.5 kg: 8 mCi/kg

<62.5 kg: 500 mCi, >62.5 kg: 8 mCi/kg

What is the main concern for patients undergoing Iobengaune I-131 therapy?

Severe and prolonged myelosuppression

Grade 4 neutropenia

Grade 4 anemia

Febrile neutropenia

All of these

None of these

Which of these occurs for patients undergoing Iobengaune I-131 therapy at only 5% of the receiving population.

Severe and prolonged myelosuppression

Grade 4 neutropenia

Grade 4 anemia

Febrile neutropenia

All of these

None of these

Piflufolastat is specific to PMSA?

True

False

Who is a candidate for Piflufolastat?

With suspected Metastasis who are candidates for initial therapy

With suspected recurrence based on elevated serum prostate specific antigen (PSA) level

Patients with prostate already removed from surgery.

Patients with previous history of melanoma

With suspected Metastasis who are candidates for initial therapy and With suspected recurrence based on elevated serum prostate specific antigen (PSA) level

What is the dose for Piflufolastat?

20 mCi

4 mCi

12 mCi

9 mCi

How soon can imaging with Piflufolastat can occur?

50 minutes

60 minutes

20 minutes

2 hours

What is the scanning region for Piflufolastat?

Skull to thigh

Top of the skull to mid thigh

Whole body

Lower abdomen to mid thigh

Piflufolastat can have misinterpretation in a variety of tumor types.

True

False

Which of these is not a adverse reaction of Piflufolastat?

Headache

Dysgeusia

Fatigue

Nausea

Lesions should be considered suspicious if uptake is greater than _______ for Piflufolastat?

Greater then physiologic uptake in that tissue or greater than adjacent background if no physiologic uptake is expected.

Less then physiologic uptake in that tissue or less than adjacent background if no physiologic uptake is expected.

Greater than uptake in sites with known tumors

Greater in sites with uptake in greater concentration to surrounding tissue.

Tumors that do not express PSMA will still be visualized.

True

False

What is the MOL for Piflufolastat?

A synthetic amino acid transported across mammalian cell membranes by amino acid transporters

Binds to cells that express PSMA, including malignant prostate cancer cells, which usually overexpress PSMA

Upon binding to somatostatin receptor expressing cells, including malignant somatostatin receptor positive tumors.

Targets the CD20 antigen on surface of normal/malignant B lymphocytes

Lu-177 Pluvicto is used for patients before Adrogen therapy and taxane-based chemotherapy.

True

False

What is the Dose for PLUVICTO? How often is it given?

200 mCi; every 6 weeks for up to 6 doses

300 mCi; every 6 weeks for up to 5 doses

200 mCi; every 4 weeks for up to 5 doses

100 mCi; every 6 weeks for up to 6 doses

What is needed before each dose of PLUVICTO?

PSA Levels

Complete blood counts

Whole body scan

Adequate hydration

If patients blood work shows inadequate RBC, WBC , and platelets, then the dose should be?

Withheld

Reduced

Permanently discontinued

Increased

Withheld, Reduced, or Permanently discontinued

PLUVICTO can cause severe liver toxicity.

True

False

MOL of PLUVICTO

Binds to cells that express PSMA, including malignant prostate cancer cells, which usually overexpress PSMA

Targets the CD20 antigen on surface of normal/malignant B lymphocytes

Binds to PSMA, a transmembrane protein that is expressed in prostate cancer, including mCRPC

A synthetic amino acid transported across mammalian cell membranes by amino acid transporters

How long should patients receiving PLUVICTO isolate from pregnant women and children?

14 days; 7 days

7 days; 14 days

5 days; 10 days

6 days; 12 days

Feedback

Arms up

Liver(14%), Pancreas(3%), Lung (7%), Red bone marrow( 12%), and Myocardium (4%).

Not specific, it may occur in other types of cancers and benign prostatic hypertrophy in primary prostate cancer.

At least 2 Liters

They will not be visualized

It is used after

Renal Toxicity

Infection, Tumor imaging, and Therapy study quiz (4/4)

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