Relier Pairs Diabetes Oral MedsVersion en ligne NUr115 Oral Diabetic Agents par Concetta Fiorentino 1 Prevents kidneys from reabsorbing glucose. 2 Possible side-effect of impaired platelet function. 3 Usually given once a day. 4 Sensitize body tissue to insulin: stimulates insulin receptor sites. 5 Stimulate pancreas to secrete insulin. 6 Enhances glucose-dependent insulin secretion. 7 Inhibit production of glucose by the liver. 8 Stimulate beta cells of the pancreas. 9 Do not increased insulin secretion. 10 Increase and prolong the action of the hormone that increases insulin release and decreases glucagon levels. 11 Drug to drug interaction with NSAIDS. Thiazolidinediones (pioglitazone (actos, rosiglitazone/Avandia) Januvia Second generation sulfonylureas (glipizide (Glucotrol) Glyburide (DiaBeta) Glimepiride (Amaryl) Biguanides (metformin (Glucophage) Metformin with glyburide (Glucovance) glipizide Non-sulfonylurea insulin secretagogues (repaglinide/Prandin, nateglinide/Starlix) Glucagon-like peptide-1 agonist (liraglutide/Victoza,, dulaglutide/Trulicity) Avandia Alpha-glucosidase inhibitors (acarbose/Precose, miglitol (Glyset) Sodium-glucose co-transporter 2 inhibitors (empagliflozin/Jardiance Dipeptidyl Pepidase-4 Inhibitors (sitagliptin/Januvia, vildagliptin /Galvus)