Relier Pairs PHA100N Barriers to medication absorptionVersion en ligne pharm par Dr. David Myers 1 Inhalation 2 intravenous 3 Oral 4 Subcutaneous, intramuscular 5 Sublingual, buccal 6 Intradermal, topical inspiratory effort capillary walls have large spaces between cells, no significant barrier. Meds must pass through the layer of cells that line the GI tract. Swallowing before dissolution allows gastric pH to inactivate the medication. NO barriers close proximity of epidermal cells