Relier Pairs Diabetes Oral MedsVersion en ligne NUr115 Oral Diabetic Agents par Concetta Fiorentino 1 Increase and prolong the action of the hormone that increases insulin release and decreases glucagon levels. 2 Inhibit production of glucose by the liver. 3 Sensitize body tissue to insulin: stimulates insulin receptor sites. 4 Stimulate pancreas to secrete insulin. 5 Stimulate beta cells of the pancreas. 6 Usually given once a day. 7 Possible side-effect of impaired platelet function. 8 Do not increased insulin secretion. 9 Enhances glucose-dependent insulin secretion. 10 Prevents kidneys from reabsorbing glucose. 11 Drug to drug interaction with NSAIDS. Januvia Sodium-glucose co-transporter 2 inhibitors (empagliflozin/Jardiance Non-sulfonylurea insulin secretagogues (repaglinide/Prandin, nateglinide/Starlix) Alpha-glucosidase inhibitors (acarbose/Precose, miglitol (Glyset) glipizide Second generation sulfonylureas (glipizide (Glucotrol) Glyburide (DiaBeta) Glimepiride (Amaryl) Avandia Biguanides (metformin (Glucophage) Metformin with glyburide (Glucovance) Thiazolidinediones (pioglitazone (actos, rosiglitazone/Avandia) Glucagon-like peptide-1 agonist (liraglutide/Victoza,, dulaglutide/Trulicity) Dipeptidyl Pepidase-4 Inhibitors (sitagliptin/Januvia, vildagliptin /Galvus)