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1. GLP-1 Receptor Agonist
2. SGLT-2 Inhibitor

Avoid in patients with impaired kidney function

Slows gastric emptying

Stimulates insulin secretion

Decreases appetite

Trulicity, Byetta, Bydureon, Victoza, Ozempic

Suppresses glucagon secretion

Use with caution in patients receiving higher dose diuretics

Increases loss of glucose in urine

Invokana, Farxiga, Jardiance

Reduces glucose reabsorption

Recommended to reduce CV risk in patient with Type 2 DM & established ASCVD

In patients with Type 2 DM and established HF, this may be considered to reduce risk of HF hospitalization