Start adequate antibiotics (proper spectrum and dose) as early as possible
Proper ventilator management with low tidal volume in patients with acute respiratory distress syndrome (ARDS)
Identify the source of infection and treat with antimicrobial therapy, surgery, or both (source control)
Alpha-/beta-adrenergic agonists (eg, norepinephrine, dopamine, dobutamine, epinephrine, vasopressin, phenylephrine)
Resuscitate the patient from septic shock by using supportive measures to correct hypoxia, hypotension, and impaired tissue oxygenation (hypoperfusion)
Source control
Volume expanders (eg, albumin)
Early and adequate antibiotic therapy
Maintain adequate organ system function, guided by cardiovascular monitoring, and interrupt the progression of MODS
Synthetic human angiotensin II
Isotonic crystalloids (eg, normal saline, lactated Ringer solution)
Early recognition
Early hemodynamic resuscitation and continued support
Antibiotics (eg, cefotaxime, ticarcillin-clavulanate, piperacillin-tazobactam, imipenem-cilastatin, meropenem, clindamycin, metronidazole, ceftriaxone, ciprofloxacin, cefepime, levofloxacin, vancomycin)
Corticosteroids (eg, hydrocortisone, dexamethasone)
