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1. Signs and symptoms of sepsis are often nonspecific and include the following:
2. Localizing signs and symptoms referable to organ systems may provide useful clues to the etiology of sepsis and are as follows:

Fatigue, malaise

Confusion

Abdominal and gastrointestinal (GI) infections – Diarrhea, abdominal pain, abdominal distention, guarding or rebound tenderness, rectal tenderness or swelling

Cardiac infections – Any new murmur, especially in patients with a history of injection or IV drug use

Anxiety

Head and neck infections – Severe headache, neck stiffness, altered mental status, earache, sore throat, sinus pain/tenderness, cervical/submandibular lymphadenopathy

Nausea and vomiting

Chest and pulmonary infections – Cough (especially if productive), pleuritic chest pain, dyspnea, dullness on percussion, bronchial breath sounds, localized rales, any evidence of consolidation

Pelvic and genitourinary (GU) infections – Pelvic or flank pain, adnexal tenderness or masses, vaginal or urethral discharge, dysuria, frequency, urgency

Bone and soft-tissue infections – Localized limb pain or tenderness, focal erythema, edema, swollen joint, crepitus in necrotizing infections, joint effusions

Difficulty breathing

Fever, chills, or rigors