Pemphigus
foliaceus
(
PF
)
is
generally
a
benign
variety
____________________
pemphigus
.
It
is
an
autoimmune
skin
disorder
____________________
by
the
loss
of
intercellular
adhesion
of
keratinocytes
in
the
____________________
parts
of
the
epidermis
(
acantholysis
)
,
resulting
in
the
formation
of
superficial
blisters
.
It
is
typified
by
clinical
involvement
of
healthy
-
appearing
skin
____________________
blisters
when
rubbed
(
the
Nikolsky
sign
;
commonly
but
incorrectly
spelled
Nicholsky
)
,
a
finding
named
after
Dr
Piotr
Nikolsky
,
who
first
____________________
this
sign
in
1896
.
[
1
]
Pemphigus
foliaceus
is
____________________
by
a
chronic
course
,
with
little
or
no
involvement
of
the
mucous
membranes
.
Pierre
Louis
Alphee
Cazenave
,
founder
of
the
first
journal
dedicated
entirely
to
dermatology
,
documented
the
first
description
of
pemphigus
foliaceus
in
1844
in
this
journal
.
The
description
was
of
a
47
-
year
-
old
woman
who
consulted
him
at
l'Hopital
Saint
Louis
in
Paris
for
a
____________________
eruption
of
several
years'
duration
.
Nikolsky
described
lateral
extension
of
the
preexisting
erosion
due
to
lifting
up
the
collarette
(
and
when
applying
a
lateral
pressure
to
the
clinically
intact
skin
)
,
whereas
Asboe
-
Hansen
described
extension
of
the
intact
____________________
due
to
pressure
that
is
applied
____________________
its
roof
.
