Patients
with
pemphigus
develop
an
autoimmune
response
____________________
against
desmosomes
.
In
patients
with
pemphigus
foliaceus
and
its
variant
,
pemphigus
____________________
,
the
target
antigen
is
desmoglein
1
.
Desmogleins
are
desmosomal
proteins
____________________
in
keratinocyte
adhesion
.
The
binding
of
autoantibodies
is
____________________
to
result
in
a
cascade
of
biochemical
intracellular
____________________
that
eventuates
in
the
loss
of
desmosome
function
.
Additionally
,
____________________
HLA
haplotypes
(
A10
or
A26
,
DRW6
)
are
thought
to
be
associated
,
suggesting
____________________
genetic
predisposition
.
