To lower the risk of disease
To improve quality of life
To preserve bone
Vaginal route cream, ring, or tablet for vaginal symptoms
Pregnancy
Severe liver disease
Colorectal cancer
Global index of chronic diseases
Total myocardial infarction
Total mortality
To provide relief of vasomotor symptoms
To reduce the risk of unwanted pregnancy
Oral
Undiagnosed vaginal bleeding
Transdermal
Personal history of breast cancer
To avoid the irregularity of menstrual cycles
Coronary artery disease (CAD)
Topical
Venous thrombosis