Active bleeding or bleeding diathesis (excluding menses)
Recent (within 2 to 4 weeks) internal bleeding
Oral anticoagulant therapy
Ischaemic stroke within 6 months, EXCEPT acute ischaemic stroke within 4.5 hours
Active peptic ulcer
Known structural cerebral vascular leeson
Severe uncontrolled hypertension (unresponsive to emergency therapy)
Suspected aortic dissection
Major surgery (<3 weeks)
Traumatic or prolonged (>10 min) CPR
