In
the
past
few
decades
,
the
discovery
of
____________________
mediators
of
the
host
response
has
led
to
the
recognition
that
the
clinical
syndrome
of
sepsis
is
the
result
of
____________________
activation
of
host
defense
mechanisms
____________________
than
the
direct
effect
of
microorganisms
.
Sepsis
and
its
sequelae
represent
a
continuum
of
clinical
and
pathophysiologic
____________________
.
Serious
bacterial
infections
at
any
site
in
the
____________________
(
see
the
image
below
)
,
with
or
without
bacteremia
,
are
usually
associated
with
important
____________________
in
the
function
of
every
organ
system
in
the
body
.
These
changes
are
____________________
mostly
by
elements
of
the
host
immune
system
against
infection
.
Shock
is
____________________
present
when
volume
replacement
fails
to
increase
blood
____________________
to
acceptable
levels
and
when
associated
clinical
evidence
indicates
inadequate
perfusion
of
major
organ
systems
,
with
progressive
____________________
of
organ
system
functions
.
Although
____________________
is
commonly
seen
in
severe
sepsis
,
its
relationship
to
hypoperfusion
is
____________________
and
is
more
often
due
to
the
acute
inflammatory
state
,
impaired
lactate
clearance
,
and
nonoxidative
phosphorylation
lactate
production
.
