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1. Clinical manifestations of metabolic syndrome include the following:
2. According to guidelines from the National Heart, Lung, and Blood Institute (NHLBI) and the American Heart Association (AHA), metabolic syndrome is diagnosed when a patient has at least 3 of the following 5 conditions:
3. Complaints of chest pain, dyspnea, or claudication (symptoms of possible complications) may warrant additional studies, including the following:
4. The following medications can be used to treat dyslipidemia and other manifestations of metabolic syndrome:

Elevated triglyceride levels: Consider niacin, fibrates, and omega-3 fatty acids

Hypertriglyceridemia

Hypertension

Hyperglycemia

Blood pressure ≥130/85 mm Hg (or receiving drug therapy for hypertension)

Reduced high-density lipoprotein cholesterol (HDL-C)

Abdominal obesity

Ultrasonography (vascular, or rest/stress echocardiography)

Chest pain or shortness of breath: Suggesting the rise of cardiovascular and other complications

Decreased HDL-C levels: Consider niacin

Electrocardiography (rest/stress ECG)

Stress single-photon emission computed tomography (SPECT) or cardiac positron emission tomography (PET)

Fasting glucose ≥100 mg/dL (or receiving drug therapy for hyperglycemia)

Hyperglycemia: Insulin-sensitizing agent, such as metformin

Elevated LDL-C levels: Statins