Clinical course:
Chronic presentation:
Adenopathy:
CBC count:
Serology:
Chronic syndromes:
Location:
History:
Sex/race/ethnicity:
Acute syndromes:
Physical examination:
Acute/subacute presentation:
Immunosuppressed presentation:
Antigen testing:
Lung infiltrate, lobar pneumonia, micronodular pattern
Thrombocytopenia in disseminated disease
Useful in testing infiltrative or chronic disease in immunosuppressed; urine antigen has ~60% sensitivity; serum antigen has ~60% sensitivity; both combined have >80% sensitivity
Pneumonia, disseminated disease in immunocompromised persons
Useful in testing immunocompetent individuals with acute or subacute disease.
Cavitary lung lesions
Common, granulomatous mediastinal involvement, can be profound, can calcify
Usually asymptomatic (if symptoms occur they are nonspecific); symptoms 3 months indicate chronic disease
No predisposition
Cavitary pulmonary lung disease, calcified lymph nodes, mediastinal fibrosis
Midwestern United States, Southeastern United States, Central America, Eastern Canada
Uncommon findings include erythema nodosum and erythema multiforme
Diffuse disease.
Large exposure includes construction sites, birds, caves; low exposure includes living in an endemic area
