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1. Nonpharmacotherapy: Lifestyle modifications used in the management of gastroesophageal reflux disease include the following
2. Pharmacotherapy: The following medications are used in the management of gastroesophageal reflux disease:
3. Surgical option: Indications for fundoplication include the following:

Refraining from ingesting food (except liquids) within 3 hours of bedtime

Avoiding bending or stooping positions

Elevating the head of the bed 8 inches

Waiting 3 hours after a meal to lie down

H2 receptor antagonists (eg, ranitidine, cimetidine, famotidine, nizatidine)

Avoiding alcohol, chocolate, citrus juice, and tomato-based products

Young patients

Patients with symptoms that are not completely controlled by proton pump inhibitors

Prokinetic agents (eg, aluminum hydroxide)

Proton pump inhibitors (eg, omeprazole, lansoprazole, rabeprazole, esomeprazole, pantoprazole)

Losing weight (if overweight)

Antacids (eg, aluminum hydroxide, magnesium hydroxide)

Poor patient compliance with medications

Eating small, frequent meals rather than large meals

The presence of extraesophageal manifestations

Patients with well-controlled reflux disease who desire definitive, one-time treatment

The presence of Barrett esophagus