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Etiology
No occupational causes or geographic predispositions are recognized ____________________ pulmonary Langerhans cell histiocytosis X ( PLCH ) . People with PLCH , almost invariably , are ____________________ smokers . Antigenic stimulation from 1 or more components of ____________________ smoke is likely responsible for the disease . Because only a few tobacco smokers develop the disease , other ____________________ factors , such as host genetics and environmental exposures , most likely ____________________ an important role in pathogenesis . Some reports in ____________________ literature also describe PLCH developing following ____________________ and / or chemotherapy for lymphoma . Additional investigation is needed to ____________________ our understanding of this disease process .