RC.Gas- Diagnostic Version en ligne Diagnostic par Yesahu Valencia 1 The infection rarely resolves spontaneously in patients with chronic infection. Hints 1 Chronic infection causes liver inflammation and fibrosis, and a significant number of these patients will develop cirrhosis and liver failure or liver cancer over a period of approximately 20 to 50 years. 2 Infection may present as an acute illness (e.g., fatigue, arthralgia, jaundice) in approximately one third of patients; however, the majority of patients are asymptomatic. 3 It is an infectious, hepatotropic virus belonging to the Flavivirus family.