Alpha Thalassemia Both fetus (HbF) and (HbA), defective remodeling and spacing protein
Amanita Phalloides
alpha helix, zinc finger, helix turn helix catalyze histone acetylation/deacetylation, recruit coactivators and corepressors.
makes antibodies to DNA and SnRNA-binding protein
patient who present with flushing, high blood calcitonin level, exhibit alternative mRNA splicing
catalyze synthesis of rRNA
synthesis hnRNA (nuclear RNA)
Betal Thalassemia in Ch 11
inhibit elongation, intercalated near G residue
a-amanitin
inhibit RNA pol II
Medullary Thyroid Cancer
RNA polymerase II
Death cap mushroom inhibit pol II and III, microfilament are stabilized . gastric lavage.
RNA polymerase I
Transcription Factors
result from hnRNA Splicing defect, hnRNA Cap site defect, poly(A) signal defect.
Actinomycin D
Defect on Ch. 16
Butterfly shaped rash. Systemic Lupus Erythematosus