Neuro Ia PharmacologyVersion en ligne Matching classifications, prototypes, actions, indications. par Norria Brice, DNP, RN, ACNP-BC 1 Classification: Ergot derivatives 2 Classification: Triptans 3 Classification: Benzodiazepines 4 Classification: Barbiturates/anxiolytics 5 Classification: Tricyclic Antidepressants (TCAs) Prototype: Ergotamine (Ergomar) Indication: tx of migraines or vascular HAs Action: Blocks alpha-adrenergic & serotonin receptor sites in brain: constriction of cranial vessels. Prototype: Sumatriptan (Imitrex) Action: binds to selective serotonin receptor sites to cause vasoconstriction of cranial vessels. Indications: Tx for acute migraines & cluster HAs Prototype: Diazepam (Valium) Action: Acts in limbic system & RAS to potentiate effects of GABA, an inhibitory neurotransmitter; may act in SC & suprasternal sites to produce muscle relaxation. Indications: tx of anxiety disorders, alcohol w/drawal, hyperexcitability/agitation, preop relief of anxiety/tension. Prototype: Phenobarbital (generic) Action: Inhibits conduction in ascending RAS; depresses cerebral cortex; alters cerebellar function; depresses motor output Indications: sedation; tx of insomnia; tx of seizures; preanesthetic. Prototype: Imipramine (Tofranil) Action: Inhibits presynaptic reuptake of norepi & serotonin; anticholinergic at CNS & peripheral receptors, sedating. Indication: relief of depression symptoms
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