50% Fatality rate b4 BM transplant
Can progress to Myelodysplasia then to Leukemia
Pancytopenia
WBC <500
Reticulocytes < 1%
Chemotherapy agents
Benzene
Pesticides- organochlorine, lindane
Ionizing radiation
Hypocellular marrow
Arsenic
Antibiotics (chloramphenicol)
