Loss of number of, and function of, nephrons
Reduced bladder tone, capacity
Decreased intracellular body water
Decreased glomerular filtration rate
Decreased kidney efficiency
Predisposed to dehydration, hypernatraemia, fluid overload, medication reactions
Increased residual urine, nocturnal urination Increased risk of incontinence
Decreased ability to concentrate and conserve H2O
Decreased secretion of sodium, H2O, urea, ammonia, and drugs
