La L-glutamina facilita la síntesis de NAD+…
.
La L-glutamina puede tener efectos beneficiosos adicionales…
.
Luego demostraron que la administración de L-glutamina aumenta modestamente los niveles de NAD + en las células falciformes…
Esto permitió al equipo del Dr. Niihara buscar antioxidantes…
.
No es una cura…
.
…which alleviate the symptoms of sickle cell disease or β-thalassemia.
…that might be of therapeutic value, a search that led them to investigate the relatively high content of nicotine adenine dinucleotide (NAD+) in sickle cells.
...by facilitating protein and glutathione synthesis.
… which appears to increase their sensitivity to oxidative stress.
...but more significantly increases the redox potential defined by the ratio of NADH to the sum of NADH plus NAD+
that might be approved by the Food and Drug Administration (FDA).
but a Phase III clinical trial indicated that it significantly reduced the frequency of sickle cell crisis in patients receiving the drug
… the normal hemoglobin A is replaced by hemoglobin S, in which the β-chain has a valine rather than a glutamic acid at position 6.
…as the substrate for the glutaminase activity of NAD synthetase, which uses the ammonia it releases from glutamine to convert nicotinic acid adenine dinucleotide to nicotinamide adenine dinucleotide.