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HJURP

Centromere

CDK

CENP-C

PLK1

CENP-A

Polo-Box Domain (PBD)

Mis18 Complex

Constitutive centromere-associated protein that binds M18BP1

Necessary for PLK1 localization to centromeres

Histone H3 variant deposited at centromeres

Specialized region of the chromosome that provides a base for kinetochore formation in mitosis

Kinase that phosphorylates M18BP1 to license CENP-A deposition

CENP-A chaperone

Dedicated CENP-A deposition machinery

Kinase that inhibits Mis18 complex formation