Hindlimb development!

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Douglas Christie

United Kingdom

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Hindlimb development!Version en ligne Use the revision tool before attempting to test your knowledge on the quiz! If you're struggling, simply go back and refresh your memory. par Douglas Christie 1 What is the function of the Apical Ectodermal Ridge (AER)? a The site of Somite growth b The site of limb bud growth / elongation c The site of bone formation d The ridge responsible for dividing the limb into anterior / posterior (cranial / caudal) axes 2 What is the signalling molecule that initiates growth of the limb bud? a TBX-4 b BMP-2 c WNT-4 d IGF-1 3 Myotomes are derived from somites. What structures do they give rise to? Written answer 4 Typically, which boney structure would be expected to ossify first? a Metatarsal b Middle phalange c Femur d Calcaneus 5 Mesenchymal cells differentiate into chondrocytes within the developing limb bud. What is the next event in the process of bone formation? a Selective cell apoptosis of newly formed chondrocytes b Cartilage is formed in between the developing joints c Formation of bone in the diaphysis of the bone d Mesenchymal cells accumulate in the diaphysis of the bone 6 Myofibres migrate from the myotomes at respective spinal roots. What structures do they form as they layer together? Written answer 7 As the hindlimb rotates, the muscles on the Pre-axial border are finally located in which compartment of the limb? a Flexor compartment b Abductor compartment c Extensor compartment d Rotator compartment 8 During which week of gestation does rotation of the hindlimb usually occur? Written answer 9 True or false, there is a 90° rotation laterally of the hindlimb before it reaches its final position a True b False 10 In the 1960's, Thalidomide was a drug prescribed to reduce symptoms of nausea for pregnant mothers. Unfortunately, the drug caused life changing defects for the embryo, which are called: a Amelia b Phocomelia c Polydactyly d Synostosis e Meromelia

Hindlimb development!Version en ligne

Use the revision tool before attempting to test your knowledge on the quiz! If you're struggling, simply go back and refresh your memory.

par Douglas Christie

What is the function of the Apical Ectodermal Ridge (AER)?

The site of Somite growth

The site of limb bud growth / elongation

The site of bone formation

The ridge responsible for dividing the limb into anterior / posterior (cranial / caudal) axes

What is the signalling molecule that initiates growth of the limb bud?

TBX-4

BMP-2

WNT-4

IGF-1

Myotomes are derived from somites. What structures do they give rise to?

Written answer

Typically, which boney structure would be expected to ossify first?

Metatarsal

Middle phalange

Femur

Calcaneus

Mesenchymal cells differentiate into chondrocytes within the developing limb bud. What is the next event in the process of bone formation?

Selective cell apoptosis of newly formed chondrocytes

Cartilage is formed in between the developing joints

Formation of bone in the diaphysis of the bone

Mesenchymal cells accumulate in the diaphysis of the bone

Myofibres migrate from the myotomes at respective spinal roots. What structures do they form as they layer together?

Written answer

As the hindlimb rotates, the muscles on the Pre-axial border are finally located in which compartment of the limb?

Flexor compartment

Abductor compartment

Extensor compartment

Rotator compartment

During which week of gestation does rotation of the hindlimb usually occur?

Written answer

True or false, there is a 90° rotation laterally of the hindlimb before it reaches its final position

True

False

In the 1960's, Thalidomide was a drug prescribed to reduce symptoms of nausea for pregnant mothers. Unfortunately, the drug caused life changing defects for the embryo, which are called:

Amelia

Phocomelia

Polydactyly

Synostosis

Meromelia

Hindlimb development!

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Hindlimb development!Version en ligne

par Douglas Christie

What is the function of the Apical Ectodermal Ridge (AER)?

What is the signalling molecule that initiates growth of the limb bud?

Myotomes are derived from somites. What structures do they give rise to?

Written answer

Typically, which boney structure would be expected to ossify first?

Mesenchymal cells differentiate into chondrocytes within the developing limb bud. What is the next event in the process of bone formation?

Myofibres migrate from the myotomes at respective spinal roots. What structures do they form as they layer together?

Written answer

As the hindlimb rotates, the muscles on the Pre-axial border are finally located in which compartment of the limb?

During which week of gestation does rotation of the hindlimb usually occur?

Written answer

True or false, there is a 90° rotation laterally of the hindlimb before it reaches its final position

In the 1960's, Thalidomide was a drug prescribed to reduce symptoms of nausea for pregnant mothers. Unfortunately, the drug caused life changing defects for the embryo, which are called: