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____________________ research is the process of reviewing previous original research to produce a more comprehensive or unique understanding of a topic of interest . ____________________ research is the process of undertaking an original study and collecting new data . A ____________________ review is a common strategy for ____________________ an explicit issue in clinical practice . ____________________ should be based on systematic reviews , but not all systematic reviews include a Meta - analysis . A meta - analysis combines the results of several studies that address a set of related research ____________________ . The ____________________ Collaboration is the oldest and largest ____________________ of systematic reviews .